Below is a list of major employers located in Saline County, including the types of products and services they provide and how many people they employ.
| Name | Product/Service | Total Employees |
|---|---|---|
| AmeriCold Logistics | Cold Storage Plant | 75 |
| Bank of America | Banking Services | 8 |
| Bank MidWest | Banking Services | 8 |
| Big Bend Retreat | Nursing Care Facility | 57 |
| Butterfield Youth Services | Child & Adolescent Treatment & related family services | 160 |
| Cargill Meat Solutions | Case Ready Pork/Beef Facility | 533 |
| Center for Human Services | Supported Employment Service for adults with disabilities | 106 |
| Central Missouri Agri Service | Grain Storage | 90 |
| City of Marshall | Municipal Service | 125 |
| City of Slater | Municipal Service | 11 |
| City of Sweet Springs | Municipal Service | 21 |
| Community Bank | Banking Services | 33 |
| Con Agra Frozen Foods | Frozen Foods | 900 |
| Coreslab | Precast & Prestressed Concrete | 100 |
| Deem's Farm Equipment | John Deere Dealer | 33 |
| Diehm's Tire Service | Tire and Automotive Sales and Service | 12 |
| Eidson Ussery Trucking Company | Trucking Company | 40 |
| Fitzgibbon Hospital/Living Center/Clinics | Acute Care & Outpatient Services | 520 |
| General Electric | Air Pollution Control Equipment | 193 |
| GENCOM, Inc. | Trucking Company | 57 |
| Gilpin Auto Parts | Re-manufactured Auto Parts & Salvage | 10 |
| Hahn & Philips Grease Co. | Blender of inedible animal greases, tallow & animal protein | 42 |
| KMMO | AM/FM Radio Station | 22 |
| KRLI/KMZU | AM/FM Radio Station | 33 |
| Kays Engineering, Inc. | Design & Build Custom & Automated Machines | 50 |
| Kent Feeds, Inc. | Livestock and Poultry Feed Manufacturing | 17 |
| Mailings Clearinghouse, Inc. | Direct Mail and Mailing List Clearing House | 80 |
| Marshall Democrat News | Daily Newspaper | 32 |
| Marshall Egg Products | Egg Processing & Cold Storage | 21 |
| Marshall Habilitation Center | State Education Center | 881 |
| Marshall Municipal Utilities | Provider of Electrical, Water and Wastewater Treatment | 91 |
| Marshall Public Schools | Education | 353 |
| Mid Missouri Energy (MME) | Ethanol Plant | 37 |
| Mid-State Seed | Seed Conditioning and Storage | 25 |
| Mid-West Quality Glove | Leather Works and Sport Gloves | 20 |
| Missouri Valley College | Four Year Liberal Arts - Co-Educational | 140 |
| Missouri Valley Community Action Agency | Serving low-income people in a 7-county area. | 150 |
| Monsanto | Ag Supply | 15 |
| Monsanto Research | Corn Research | 6 |
| Riggins R-Co. | Ag. Equipment Dealer/Sales/Service | 24 |
| Salt Fork YMCA | Community Center | 65 |
| Wal-Mart | Discount Store | 300 |
| W.B. Young | Metal Fabrications | 50 |
| Wood and Huston Bank | Banking Services | 90 |